Biochip using nano-scale 3D printing organic materials

Making biochips is a key technology for disease research and is now becoming easier. The new nano-printing process uses gold-plated pyramids, LED light sources, and photochemical reactions to print more organic material on the surface of a single biochip than ever before.

Equipment appearance

The technology uses a series of polymer pyramids that are covered in gold and mounted on an atomic force microscope. These 1cm square arrays contain thousands of small pyramids with holes that allow light to pass through, and ensure that light passes through only specific locations on the surface of the chip, holding delicate organic matter to the surface of the chip and not Damage them.

Such sophisticated lithography processes are widely considered to be the best way to use nanoscale 3D printing of organic materials. But in the past, they were limited in that they could only print one molecule at a time.

Chip to be printed

Now researchers at the University of New York City Advanced Research Center (ASRC) and Hunt College believe they have solved this problem.

Printing principle

They are using microfluidic technology, which manipulates fluids at the molecular level and delivers the desired combination of compounds to designated locations on the biochip. Then they use photochemical reactions, that is, light passes through the small pyramid mentioned earlier. When light reacts with molecules, it sticks them on the chip.

With a typical lithography system, the energy of light can be overloaded, destroying some molecules. However, the City University of New York team used beam lithography to limit the light to a small vertex. This allows the team to control the light and protect the organic material that has been printed on the biochip.

Adam Braunschweig, associate researcher at the ASRC Nanoscience Initiative and the Department of Chemistry at Hunt College, said that this 3D printed biochip approach will allow scientists to understand the fast lanes of cells and organisms. This is because this technology should make it easier and more effective to study the development of diseases and solve other biological problems, such as detecting bioterrorism drugs.

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